HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzo(B)Thiophene → a-(2-Benzo[b]thienyl)-4-methoxybenzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzo(B)Thiophene | HCID 7221 | — |
| Reactant | 4-Methoxybenzaldehyde | HCID 31244 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | a-(2-Benzo[b]thienyl)-4-methoxybenzyl alcohol | HCID 49962600 | — |
Reaction Steps
a-(2-benzo[b]thienyl)-4-methyoxybenzyl alcohol was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles. 1.0 g), t-BuLi (1.7 m, 10.4 mmoles, 6.1 ml), 4-methoxy-benzaldehyde (8.9 mmoles, 1.1 ml) and THF (20 ml). Flash chromatography (20% ethyl acetate/hexanes) provided 1.75 g (87%) of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331637B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-9effa865e5904419b40acc501fe42e12 |
| Source note | uspto-grants-2001_12 |