4-Bromo-3-methylisoxazol-5-amine → HCID 23445242, compound

HRID 2270692Notes

Reaction equation

HRID 2270692 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].Cl[S:10]([C:13]1[CH:17]=[CH:16][S:15][C:14]=1[CH2:18][C:19]1[CH:24]=[CH:23][C:22]2[O:25][CH2:26][O:27][C:21]=2[CH:20]=1)(=[O:12])=[O:11]>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:10]([C:13]1[CH:17]=[CH:16][S:15][C:14]=1[CH2:18][C:19]1[CH:24]=[CH:23][C:22]2[O:25][CH2:26][O:27][C:21]=2[CH:20]=1)(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998401HCID 22998401, compound

Product 1

HCID 23445242HCID 23445242, compoundYield 37%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy)benzyl]-thiophene-3-sulfonamide was prepared in the same manner as described in Example 2 by reacting 5-amino-4-bromo-3-methylisoxazole and 3-chlorosulfonyl-2-[(3,4-methylenedioxy)benzyl]thiophene. The crude product was purified by HPLC, 37% yield.

Workup

  1. customThe crude product was purified by HPLC, 37% yield

Sources & evidence

ORD record
ord-a1e1e4ae40af4b3488d497e734e2524e
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

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