HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 3-(2,3-Dihydro-benzo[1,4]dioxine-6-carbonyl)-1-(6-methyl-pyridin-2-ylmethyl)-1h-quinolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-(6-Methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl amide | HCID 57754512 | — |
| Solvent | Magnesium bromide 2,3-dihydro-1,4-benzodioxin-6-ide (1/1/1) | HCID 15974803 | — |
| Product | 3-(2,3-Dihydro-benzo[1,4]dioxine-6-carbonyl)-1-(6-methyl-pyridin-2-ylmethyl)-1h-quinolin-4-one | HCID 57754514 | — |
Reaction Steps
Experimental conditions analogous to those described for Step 6 of Example 60, from 161 mg (0.48 mmol) of 1-(6-methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 2.5 mL THF and 2.4 mL 0.5M 3,4-(ethylenedioxy)phenylmagnesium bromide. Yield: 65 mg of a white solid. LC-MSD, m/z for C25H20N2O4 [M+H]+=413.1; HPLC retention time: 1.8 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-7fa5f74d6c2b4f34ac57ae07e1582d11 |
| Source note | uspto-grants-2009_07 |