5-Iodo-2-(trifluoromethyl)pyridine → 1-(6-Methyl-pyridin-2-ylmethyl)-3-(6-trifluoromethyl-pyridine-3-carbonyl)-1H-quinolin-4-one

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60, from 120 mg (0.36 mmol) of 1-(6-methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 214 mg (0.78 mmol) of 5-iodo-2-trifluoromethyl-pyridine in 1.5 mL THF with 0.41 mL 2M isopropylmagnesium chloride. Yield: 81 mg of a white powder. LC-MSD, m/z for C23H16F3N3O2 [M+H]+=424.1; HPLC retention time: 2.2 min.

Provenance & Evidence