HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → 2-[(4-Methylphenoxy)methyl]thiophene-3-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Sodium hydroxide ethanol | HCID 23692425 | — |
| Reactant | 2-[(4-Methylphenoxymethyl]thiophene-3-sulfonyl}pyrrole | HCID 86583961 | — |
| Product | 2-[(4-Methylphenoxy)methyl]thiophene-3-sulfonyl chloride | HCID 23445257 | 46% |
Reaction Steps
2-[(4-methylphenoxy)methyl]thiophene-3-sulfonyl chloride was prepared, as described in Example 64E, using N-{2-[(4-methylphenoxymethyl]thiophene-3-sulfonyl}pyrrole by basic hydrolysis (NaOH/EtOH) followed by conversion to the corresponding sulfonyl chloride, in 46% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331637B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-f4428b8ecd154c629b05ffb84f862042 |
| Source note | uspto-grants-2001_12 |