HCID 60115138, compound → HCID 68821581, compound

HRID 2270764Notes

Reaction equation

HRID 2270764 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:34]=[CH:35][CH:36]=1)[C:5]([NH:7][CH2:8][C@@H:9]([C:31]([OH:33])=[O:32])[NH:10][C:11](=[O:30])[C:12]1[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([OH:28])[CH:23]=2)=[O:19])=[CH:14][C:13]=1[Cl:29])=[O:6].ClC1C=CC=CC=1C(NC[C@@H](C(O)=O)NC(=O)C1C=CC(C(NCC2C=CC=C(O)C=2)=O)=CC=1Cl)=O.ClC1C=C(C=CC=1)C(NC[C@@H](C(O)=O)NC(=O)C1C=CC(C(NCC2C=CC=C(O)C=2)=O)=CC=1Cl)=O.ClC1C=CC(C(NC[C@@H](C(O)=O)NC(=O)C2C=CC(C(NCC3C=CC=C(O)C=3)=O)=CC=2Cl)=O)=CC=1.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C1C=CC=C(F)C=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C1C=CC=C(I)C=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C1C=C(F)C=C(F)C=1)=O.ClC1C=C(C=C(F)C=1)C(NC[C@@H](C(O)=O)NC(=O)C1C=CC(C(NCC2C=CC=C(O)C=2)=O)=CC=1Cl)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C1C=C(Cl)C=C(Cl)C=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C1C=C([Br:344])C=C(Br)C=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C1C=C(F)C(F)=CC=1F)=O>>[Br:344][C:34]1[CH:35]=[CH:36][CH:2]=[CH:3][C:4]=1[C:5]([NH:7][CH2:8][C@@H:9]([C:31]([OH:33])=[O:32])[NH:10][C:11](=[O:30])[C:12]1[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([OH:28])[CH:23]=2)=[O:19])=[CH:14][C:13]=1[Cl:29])=[O:6]

Participants

12

Reactant 11

HCID 60115138HCID 60115138, compoundHCID 60115140HCID 60115140, compoundHCID 68819740HCID 68819740, compoundHCID 68819751HCID 68819751, compoundHCID 68820906HCID 68820906, compoundHCID 68820909HCID 68820909, compoundHCID 68821778HCID 68821778, compoundHCID 68822982HCID 68822982, compoundHCID 68823084HCID 68823084, compoundHCID 68823407HCID 68823407, compoundHCID 68823694HCID 68823694, compound

Product 1

HCID 68821581HCID 68821581, compound

Procedure

3-(3-bromobenzoyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; 3-(2-chlorobenzoyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; 3-(3-chlorobenzoyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; 3-(4-chlorobenzoyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3-fluorobenzoyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3-iodobenzoyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3,5-difluorobenzoyl)amino-L-alanine; 3-(3-chloro-5-fluorobenzoyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3,5-dichlorobenzoyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3,5-dibromobenzoyl)amino-L-alanine); N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(2,4,5-trifluorobenzoyl)amino-L-alanine).

Sources & evidence

ORD record
ord-ece267ce063e467dae7916d860e9e886
Source dataset
uspto-grants-2001_12
Patent number
US06331640B1

Reaction notes

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