HCID 68822019, compound → HCID 20714634, compound

HRID 2270767Notes

Reaction equation

Br[C:2]1C=C2C(=C[CH:11]=1)NC(=O)CC2C(NC[C@@H](C(O)=O)NC(=O)C1C=CC(C(NCC2C=CC=C(O)C=2)=O)=CC=1Cl)=O.[Cl:42][C:43]1[CH:68]=[C:67]([C:69]([NH:71][CH2:72][C:73]2[CH:78]=[CH:77][CH:76]=[C:75]([OH:79])[CH:74]=2)=[O:70])[CH:66]=[CH:65][C:44]=1[C:45]([NH:47][C@H:48]([C:62]([OH:64])=[O:63])[CH2:49][NH:50][C:51]([C:53]1O[C:55]2[CH:61]=[CH:60][CH:59]=[CH:58][C:56]=2[CH:57]=1)=[O:52])=[O:46]>>[Cl:42][C:43]1[CH:68]=[C:67]([C:69]([NH:71][CH2:72][C:73]2[CH:78]=[CH:77][CH:76]=[C:75]([OH:79])[CH:74]=2)=[O:70])[CH:66]=[CH:65][C:44]=1[C:45]([NH:47][C@H:48]([C:62]([OH:64])=[O:63])[CH2:49][NH:50][C:51]([CH:53]1[CH2:11][CH2:2][C:55]2[C:56](=[CH:58][CH:59]=[CH:60][CH:61]=2)[CH2:57]1)=[O:52])=[O:46]

Participants

Reactant 2

HCID 68822019HCID 68822019, compound

HCID 68823532HCID 68823532, compound

Product 1

HCID 20714634HCID 20714634, compound

Procedure

N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(DL-7-methoxy-1,2,3,4,4αβ,9,10,10αβ-octahydro-2β-phenanthrenecarbonyl)]amino-L-alanine; 3-(6-bromo-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(benzofuran-2-carbonyl)amino-L-alanine;

Sources & evidence

ORD record: ord-16d59be76a6d4d208b9369ef88484661
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06331640B1

Reaction notes

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