HCID 4522873, compound → HCID 68820666, compound

HRID 2270769Notes

Reaction equation

HRID 2270769 reaction equation
[Cl:1][C:2]1[CH:25]=[C:24]([C:26]([NH:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([OH:36])[CH:31]=2)=[O:27])[CH:23]=[CH:22][C:3]=1[C:4]([NH:6][C@H:7]([C:19]([OH:21])=[O:20])[CH2:8][NH:9][C:10](=[O:18])[CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15]C[CH2:13]1)=[O:5].ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1C=CC=CC=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1C=CC(OC)=CC=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1C=CC([N+]([O-])=O)=CC=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1C=CC=C(C(F)(F)F)C=1)=O.[N+](C1C=C(CC(NC[C@@H](C(O)=O)N)=O)C=C([N+]([O-])=O)C=1)([O-])=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1SC=CC=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1C=NC=CC=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1C=CC2C(=CC=CC=2)C=1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC1C2C=CC=CC=2C2C1=CC=CC=2)=O.S1C2C=CC=CC=2[NH+]=C1>>[Cl:1][C:2]1[CH:25]=[C:24]([C:26]([NH:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([OH:36])[CH:31]=2)=[O:27])[CH:23]=[CH:22][C:3]=1[C:4]([NH:6][C@H:7]([C:19]([OH:21])=[O:20])[CH2:8][NH:9][C:10](=[O:18])[CH2:11][CH:12]1[CH2:13][CH2:15][CH2:16][CH2:17]1)=[O:5]

Participants

12

Reactant 11

HCID 4522873HCID 4522873, compoundHCID 68819226HCID 68819226, compoundHCID 68819376HCID 68819376, compoundHCID 68819782HCID 68819782, compoundHCID 68820895HCID 68820895, compoundHCID 68820897HCID 68820897, compoundHCID 68821370HCID 68821370, compoundHCID 68821472HCID 68821472, compoundHCID 68822983HCID 68822983, compoundHCID 68823527HCID 68823527, compoundHCID 86757683HCID 86757683, compound

Product 1

HCID 68820666HCID 68820666, compound

Procedure

N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(cyclohexylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(phenylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(4-methoxyphenylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(4-nitrophenylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3-trifluoromethylphenylacetyl)amino-L-alanine; N-[2-chloro-4-[[[3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3,5-dinitrophenylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(2-thienylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3-pyridylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(2-naphthylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(9H-fluoren-9-ylacetyl)amino-L-alanine; 3-[[(2S)-2-carboxy-2-[2-chloro-4-[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoylamino]ethylaminocarbonyl]methyl]benzothiazol-3-ium salt)

Sources & evidence

ORD record
ord-e0d42950a0b540e3a2808c6185509159
Source dataset
uspto-grants-2001_12
Patent number
US06331640B1

Reaction notes

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