HCID 20714642, compound → HCID 68819104, compound

HRID 2270770Notes

Reaction equation

HRID 2270770 reaction equation
[Cl:1][C:2]1[CH:27]=[C:26]([C:28]([NH:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=2)=[O:29])[CH:25]=[CH:24][C:3]=1[C:4]([NH:6][C@H:7]([C:21]([OH:23])=[O:22])[CH2:8][NH:9][C:10](=[O:20])[CH2:11][CH2:12][C:13]1[C:14]([CH3:19])=NO[C:17]=1[CH3:18])=[O:5].Cl[C:40]1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CCN1CCCCC1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CC(=O)CC(C1C=CC=CC=1)C)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)[C@@H](N1C=CC=C1)CC1CCCCC1)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C(C)(C)C)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)C(C)C)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(=O)CC(C)C)=O>>[Cl:1][C:2]1[CH:27]=[C:26]([C:28]([NH:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=2)=[O:29])[CH:25]=[CH:24][C:3]=1[C:4]([NH:6][C@H:7]([C:21]([OH:23])=[O:22])[CH2:8][NH:9][C:10](=[O:20])[CH2:11][CH2:12][C:13]1[CH:17]=[CH:18][CH:40]=[CH:19][CH:14]=1)=[O:5]

Participants

8

Reactant 7

HCID 20714642HCID 20714642, compoundHCID 68819439HCID 68819439, compoundHCID 68820322HCID 68820322, compoundHCID 68820614HCID 68820614, compoundHCID 68820837HCID 68820837, compoundHCID 68821490HCID 68821490, compoundHCID 68859985HCID 68859985, compound

Product 1

HCID 68819104HCID 68819104, compound

Procedure

N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dimethylisoxazol-4-yl)propanoyl]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[3-(piperidin-1-yl)propanoyl]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3RS)-3-phenylbutanoyl]-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3-cyclohexyl-(2S)-2-(1-pyrrolyl)propanoyl)]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(trimethylacetyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(2-methylpropanoyl)amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(3-methylbutanoyl)amino-L-alanine).

Sources & evidence

ORD record
ord-05e77e8f449c419ba765ec80af3d4dd2
Source dataset
uspto-grants-2001_12
Patent number
US06331640B1

Reaction notes

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