N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-[(5-methylthiophene-2-carbonyl)]amino-L-alanine → 3-(benzoylamino)-N-[2-chloro-4-[[(2,3-dihydro-2-oxo-1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-L-alanine

HRID 2270772Notes

Reaction equation

HRID 2270772 reaction equation
[C:1]([NH:9][CH2:10][C@@H:11]([C:35]([OH:37])=[O:36])[NH:12][C:13](=[O:34])[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:32]=[CH:31][CH:30]=[C:29]3[C:25]=2[CH:26]=[CH:27][NH:28]3)=[O:21])=[CH:16][C:15]=1[Cl:33])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1C=C(C(NCC2C3N=CNC=3C=CC=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=[O:42].ClC1C=C(C(NCC2C=CC=C3C=2C=CN3)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=O.ClC1C=C(C(NCC2C=CC=C3C=2CCN3)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=O.BrC1C=C(C(NCC2C=CC=C3C=2C=CN3)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=O.ClC1C=C(C(NCC2C=CC=C3C=2C=CN3)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1C=CSC=1)=O)=O.ClC1C=C(C(NCC2C=CC=C3C=2C=CN3)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC(C)=CC=1)=O)=O.ClC1C=C(C(NCC2C=CC=C3C=2C=NN3)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=O>>[C:1]([NH:9][CH2:10][C@@H:11]([C:35]([OH:37])=[O:36])[NH:12][C:13](=[O:34])[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:32]=[CH:31][CH:30]=[C:29]3[C:25]=2[CH2:26][C:27](=[O:42])[NH:28]3)=[O:21])=[CH:16][C:15]=1[Cl:33])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

9

Reactant 8

HCID 23523065N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-[(5-methylthiophene-2-carbonyl)]amino-L-alanineHCID 59977260N-[2-chloro-4-[[[(1H-indazol-4-yl)methyl]amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanineHCID 59977269N-[2-bromo-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanineHCID 59977273N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-3-carbonyl)amino-L-alanineHCID 59977277N-[2-chloro-4-[[(1H-benzimidazol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanineHCID 599773083-(benzoylamino)-N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-L-alanineHCID 60115142N-[2-chloro-4-[[(2,3-dihydro-1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanineHCID 68819411N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine

Product 1

HCID 599772933-(benzoylamino)-N-[2-chloro-4-[[(2,3-dihydro-2-oxo-1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-L-alanine

Procedure

3-(benzoylamino)-N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-L-alanine; N-[2-chloro-4-[[(1H-benzimidazol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine; N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbony]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine; N-[2-chloro-4-[[(2,3-dihydro-1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine; N-[2-bromo-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine; N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-(thiophene-3-carbonyl)anino-L-alanine; N-[2-chloro-4-[[(1H-indol-4-ylmethyl)amino]carbonyl]benzoyl]-3-[(5-methylthiophene-2-carbony)]amino-L-alanine), and N-[2-chloro-4-[[[(1H-indazol-4-yl)methyl]amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine.

Sources & evidence

ORD record
ord-c3247412d7564f5582ae68ac5529253e
Source dataset
uspto-grants-2001_12
Patent number
US06331640B1

Reaction notes

Loading…