HRID2270773

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H](NC(=O)c1cc(Cl)c(C(=O)N[C@@H](CNC(=O)c2cccs2)C(=O)O)c(Cl)c1)c1cccc2ccccc12

HCID54166190

未命名化合物

PRODUCTS

生成物

结构：CCCCS(=O)(=O)NC[C@H](NC(=O)c1ccc(C(=O)N[C@H](C)c2cccc3ccccc23)cc1Cl)C(=O)O

HCID54346209

未命名化合物

PROCEDURE

实验过程

3-[(2-acetamido-4-methylthiazol-5-yl)sulfonyl]amino-N-[2-chloro-4-[[[(1R)-1-(1-naphthalenyl)ethyl]amino]carbonyl]benzoyl]-L-alanine; N-[2,6-dimethyl-4-[[[(1R)-1-(1-naphthalenyl)ethyl]amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine; N-[2-bromo-4-[[[(1R)-1-(1-naphthalenyl)ethyl]amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine), and N-[2,6-dichloro-4-[[[(1R)-1-(1-naphthalenyl)ethyl]amino]carbonyl]benzoyl]-3-[(thiophene-2-carbonyl)amino]-L-alanine;

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-55631affa3d24ac198cf89d98011ee18
来源数据集: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06331640B1
来源说明: uspto-grants-2001_12

反应 SMILES

C(NC1S[C:7]([S:11]([NH:14][CH2:15][C@@H:16]([C:42]([OH:44])=[O:43])[NH:17][C:18](=[O:41])[C:19]2[CH:24]=[CH:23][C:22]([C:25]([NH:27][C@@H:28]([C:30]3[C:39]4[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=4)[CH:33]=[CH:32][CH:31]=3)[CH3:29])=[O:26])=[CH:21][C:20]=2[Cl:40])(=[O:13])=[O:12])=[C:8]([CH3:10])N=1)(=O)C.[CH3:45]C1C=C(C(N[C@@H](C2C3C(=CC=CC=3)C=CC=2)C)=O)C=C(C)C=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=O.BrC1C=C(C(N[C@@H](C2C3C(=CC=CC=3)C=CC=2)C)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=O.ClC1C=C(C(N[C@@H](C2C3C(=CC=CC=3)C=CC=2)C)=O)C=C(Cl)C=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1)=O)=O>>[CH2:7]([S:11]([NH:14][CH2:15][C@@H:16]([C:42]([OH:44])=[O:43])[NH:17][C:18](=[O:41])[C:19]1[CH:24]=[CH:23][C:22]([C:25]([NH:27][C@@H:28]([C:30]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH:33]=[CH:32][CH:31]=2)[CH3:29])=[O:26])=[CH:21][C:20]=1[Cl:40])(=[O:12])=[O:13])[CH2:8][CH2:10][CH3:45]