2-Chloro-5-iodopyridine → HCID 57754623, compound

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60, from 800 mg (2.37 mmol) of 1-(6-methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 25 mL THF and 1.25 g (5.22 mmol) of 2-chloro-5-iodo-pyridine in 7 mL THF with 2.73 mL 2M isopropylmagnesium chloride. Yield: 635 mg of a white powder. LC-MSD, m/z for C22H16ClN3O2 [M+H]+=390.1, 392.0; HPLC retention time: 2.0 min.

Provenance & Evidence