1-(3-Chloro-benzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide → 1-(3-Chloro-benzyl)-3-(4-methoxy-benzoyl)-1H-quinolin-4-one

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60, from 300 mg (0.84 mmol) of 1-(3-chloro-benzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 3 mL THF and 3.7 mL 0.5M 4-methoxyphenylmagnesium bromide. Yield: 168 mg of a white solid. LC-MSD, m/z for C24H18ClNO3 [M+H]+=404.1, 406.0; HPLC retention time: 2.4 min.

Provenance & Evidence