Methyl 3-oxo-3-phenylpropanoate → Methyl 3-hydroxy-3-phenylpropanoate

Participants

Reaction Conditions

Reaction Steps

A2.3 mg (0.0014 mmol) portion of the thus obtained complex, 0.5 g (2.8 mmol) of methyl benzoylacetate and 2 ml of methanol were put into a stainless steel autoclave and stirred at 50° C. for 14 hours under a hydrogen pressure of 30 atm to obtain optically active methyl 3-phenyl-3-hydroxypropionate. When measured by HPLC, the conversion ratio was 100% and its optical purity was 96.5% ee.

Provenance & Evidence