Sodium Methoxide → HCID 18403019, compound

HRID 2270904Notes

Reaction equation

HRID 2270904 reaction equation
[Cl:1][C:2]1[C:7]([O:8][C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:6][C:5]([N:19]=[C:20]2[N:28]3[N:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[C:22](=[O:29])[S:21]2)=[C:4]([F:30])[CH:3]=1.C[O-].[Na+]>CO>[Cl:1][C:2]1[C:7]([O:8][C:9]2[C:14]([C:15]([F:16])([F:17])[F:18])=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:6][C:5]([N:19]2[C:22](=[O:29])[N:23]3[CH2:24][CH2:25][CH2:26][CH2:27][N:28]3[C:20]2=[S:21])=[C:4]([F:30])[CH:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 18402923HCID 18402923, compound

Product 1

HCID 18403019HCID 18403019, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

9-[4-Chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenylimino]-8-thia-1,6-diazabicyclo[4,3,0]nonan-7-one (see Example 8) (0.2 g) was mixed with methanol (18 ml) and a catalytic amount of sodium methoxide added. The mixture was heated at reflux for 0.5 hour and the solvent removed under reduced pressure. Column chromatography (silica gel, hexane:ethyl acetate, 3:2) yielded the product (0.2 g, 100%).

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 0.5 hour
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-3153d24e10f64995b7472c84c033b7d6
Source dataset
uspto-grants-2001_12
Patent number
US06333296B1

Reaction notes

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