Sodium hydride → HCID 57754667, compound

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 6 of Example 60, from 71 mg (0.22 mmol) of 3-(6-trifluoromethyl-pyridine-3-carbonyl)-1H-quinolin-4-one, 11 mg (0.27 mmol) of 60% sodium hydride, 67 mg (0.27 mmol) of 3-bromobenzyl bromide and 1 mL of N,N-dimethylformamide. Yield: 85 mg of a white solid: LC-MSD, m/z for C23H14BrF3N2O2 [M+H]+=487.0, 489.0; HPLC retention time: 2.7 min.

Provenance & Evidence