1-Methylhomopiperazine → 5-Chloro-7-methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole

HRID 2270959Notes

Reaction equation

HRID 2270959 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:13][N:14]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8]([N:17]3[CH2:18][CH2:19][CH2:20][N:14]([CH3:13])[CH2:15][CH2:16]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 178426087HCID 178426087, compound

Product 1

HCID 97956755-Chloro-7-methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5-Chloro-7-methyl-2-mercaptobenzoxazole (200 mg) was dissolved in toluene (10 ml), N-methylhomopiperazine (1.24 ml) was added dropwise to the solution and then the mixture was stirred with heating for 1 hour. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1) to obtain the title compound 5-chloro-7-methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole (266 mg).

Workup

  1. temperaturewith heating for 1 hour
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1)

Sources & evidence

ORD record
ord-17ee0117d02a444381fe7e1322fedf47
Source dataset
uspto-grants-2001_12
Patent number
US06333328B1

Reaction notes

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