1-Methylhomopiperazine → HCID 22558202, compound

HRID 2270960Notes

Reaction equation

HRID 2270960 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:12][CH3:13])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:14][N:15]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:12][CH3:13])[C:5]2[O:9][C:8]([N:18]3[CH2:19][CH2:20][CH2:21][N:15]([CH3:14])[CH2:16][CH2:17]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 178436491HCID 178436491, compound

Product 1

HCID 22558202HCID 22558202, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5-Chloro-7-ethyl-2-mercaptobenzoxazole (200 mg) was dissolved in toluene (10 ml), N-methylhomopiperazine (1.17 ml) was added dropwise to the solution and then the mixture was stirred with heating for 5 hours. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1) to obtain the title compound 5-chloro-7-ethyl-2-(4-methyl-1-homopiperazinyl)benzoxazole (211 mg).

Workup

  1. temperaturewith heating for 5 hours
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1)

Sources & evidence

ORD record
ord-2f8ead096c8d46f9b837a6e3b62a80d9
Source dataset
uspto-grants-2001_12
Patent number
US06333328B1

Reaction notes

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