HCID 12242302, compound → HCID 22558197, compound

HRID 2270965Notes

Reaction equation

HRID 2270965 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[NH:13]1[CH2:20][CH2:19][CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8]([N:13]3[CH2:20][CH2:19][CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 12242302HCID 12242302, compoundHCID 178424102HCID 178424102, compound

Product 1

HCID 22558197HCID 22558197, compoundYield 171.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5,7-Dimethyl-2-mercapto-benzoxazole (109 mg) was dissolved in toluene (6 ml), and the solution was mixed with 1,4-diazacyclooctane (1.93 g) which has been obtained in accordance with the method described in Carib. J. Sci., 14, 77 (1974) and then stirred with heating for 3 hours. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=5:1) to obtain the title compound 5,7-dimethyl-2-(1,4-diazacyclooctanyl)benzoxazole (271 mg).

Workup

  1. customhas been obtained in accordance with the method
  2. temperaturewith heating for 3 hours
  3. customAfter evaporation of the solvent
  4. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=5:1)

Sources & evidence

ORD record
ord-8989d98e735a4895876527d6fe144aec
Source dataset
uspto-grants-2001_12
Patent number
US06333328B1

Reaction notes

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