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Sodium hydride → 7-(3,4-Dimethyl-benzoyl)-5-pyridin-3-ylmethyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-(Bromomethyl)pyridine hydrobromide | HCID 12707037 | — |
| 反応物 | 7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | HCID 53337338 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-(3,4-Dimethyl-benzoyl)-5-pyridin-3-ylmethyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | HCID 16730772 | — |
反応手順
Experimental conditions analogous to those described for Step 3 of Example 1, from 71 mg (0.22 mmol) of 7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one, 23 mg of 60% sodium hydride, 72 mg of 3-bromomethylpyridine hydrobromide and 1.3 mL of N,N-dimethylformamide. Yield: 45 mg of a white solid: LC-MSD, m/z for C25H20N2O4 [M+H]+=413.5; HPLC retention time: 1.5 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557213B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-7a9eff4cbfbc4ad3a4875af91fa2398a |
| 出典メモ | uspto-grants-2009_07 |