Benzyl chloroformate → HCID 54346849, compound

Participants

Reaction Steps

To a solution of (2R)-4-methanesulfonylpiperazine-2-carboxylic acid hydrochloride (2.10 g) in H2O (20 ml) and dioxane (20 ml) were added NaHCO3 (2.38 g) and a solution of benzyloxycarbonyl chloride (1.76 g) in Et2O (10 ml) at room temperature. After stirring for 2 hours, Et2O and dioxane were evaporated in vacuo. The solution was acidified with 1N HCl and extracted with AcOEt (80 ml). The organic layer was washed with brine, dried over MgSO4 and concentrated in vacuo to give 3.0 g of (2R)-1-benzyloxycarbonyl-4-methanesulfonylpiperazine-2-carboxylic acid as an amorphous powder.

Provenance & Evidence