HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 7-(3,4-Dimethyl-benzoyl)-5-pyridin-4-ylmethyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Bromomethyl)pyridine hbr | HCID 12752219 | — |
| Reactant | 7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | HCID 53337338 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(3,4-Dimethyl-benzoyl)-5-pyridin-4-ylmethyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | HCID 16730771 | — |
Reaction Steps
Experimental conditions analogous to those described for Step 3 of Example 1, from 71 mg (0.22 mmol) of 7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one, 23 mg of 60% sodium hydride, 72 mg of 4-bromomethylpyridine hydrobromide and 1.3 mL of N,N-dimethylformamide. Yield: 61 mg of a white solid: LC-MSD, m/z for C25H20N2O4 [M+H]+=413.5; HPLC retention time: 1.2 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-f7041c322a1a40e8ba3404d141236fdc |
| Source note | uspto-grants-2009_07 |