Potassium Hydroxide → HCID 131723050, compound

HRID 2271048Notes

Reaction equation

HRID 2271048 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH2:14][CH2:15][CH2:16][CH2:17][C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:27]([O:29]C)=[O:28])[CH:25]=3)[NH:20][CH:19]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>C(O)C>[OH2:28].[CH2:1]([CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH2:14][CH2:15][CH2:16][CH2:17][C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:27]([OH:29])=[O:28])[CH:25]=3)[NH:20][CH:19]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 15857346HCID 15857346, compound

Product 1

HCID 131723050HCID 131723050, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 3-[4-(3-benzylpiperidin-1-yl)butyl]indole-5-carboxylate and KOH is heated under reflux in ethanol. After customary work-up, 3-[4-(3-benzylpiperidin-1-yl)butyl]-5-carboxyindole, hydrate, m.p. 144-147°, is obtained.

Workup

  1. temperatureis heated

Sources & evidence

ORD record
ord-1cf974c5d0a141279d60316936da0eac
Source dataset
uspto-grants-2001_12
Patent number
US06333339B1

Reaction notes

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