HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 1-(6-bromo-pyridin-2-ylmethyl)-3-(3,4-dimethyl-benzoyl)-6,7-difluoro-1H-quinolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| Reactant | 2-Bromo-6-(bromomethyl)pyridine | HCID 12954796 | — |
| Reactant | 3-(3,4-dimethyl-benzoyl)-6,7-difluoro-1H-quinolin-4-one | HCID 57754789 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(6-bromo-pyridin-2-ylmethyl)-3-(3,4-dimethyl-benzoyl)-6,7-difluoro-1H-quinolin-4-one | HCID 57754743 | — |
Reaction Steps
Experimental conditions analogous to those described for Step 3 of Example 1, from 74 mg (0.24 mmol) of 3-(3,4-dimethyl-benzoyl)-6,7-difluoro-1H-quinolin-4-one, 71 mg (0.28 mmol) of 2-bromo-6-bromomethyl-pyridine, 0.57 mL of 0.5M toluene solution of potassium bis(trimethylsilyl)amide and 2 mL of THF. Yield: 73 mg of a white solid: LC-MSD, m/z for C24H17BrF2N2O2 [M+H]+=483.4, 485.4; HPLC retention time: 2.6 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-06249ba5c4e84b3f88f43c99eb24d0de |
| Source note | uspto-grants-2009_07 |