Sodium hydride → HCID 57754608, compound

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 3 of Example 1, from 50 mg (0.17 mmol) of 3-(5,6-dimethyl-pyridine-3-carbonyl)-6-fluoro-1H-quinolin-4-one, 8 mg (0.20 mmol) of 60% sodium hydride and 51 mg (0.20 mmol) of 2-bromo-6-bromomethyl-pyridine and 0.7 mL of N,N-dimethylformamide. Yield: 38 mg of a white solid: LC-MSD, m/z for C23H17BrFN3O2 [M+H]+=466.2, 468.1; HPLC retention time: 2.1 min.

Provenance & Evidence