HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl iodide → 5-(N-butyl-N-methylsulfonylamino)-2,3,4,5-tetrahydro-1-benzoxepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl iodide | HCID 10962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-Methylsulfonylamino-2,3,4,5-tetrahydro-1-benzoxepine | HCID 22391790 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(N-butyl-N-methylsulfonylamino)-2,3,4,5-tetrahydro-1-benzoxepine | HCID 22391776 | — |
Reaction Steps
1.0 g of 5-methylsulfonylamino-2,3,4,5-tetrahydro-1-benzoxepine (Example 8a) were reacted with sodium hydride and iodobutane in DMF analogously to Example 11. After recrystallization of the crude product (1.0 g) from isopropanol, 0.4 g of 5-(N-butyl-N-methylsulfonylamino)-2,3,4,5-tetrahydro-1-benzoxepine was obtained, m.p. 78-79° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06333349B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-706621bffc114e4b8cc7a6baa0cdd40c |
| Source note | uspto-grants-2001_12 |