HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 7-Chloro-9-methyl-5-methylsulfonylamino-2,3,4,5-tetrahydro-1-benzoxepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 5-Amino-7-chloro-9-methyl-2,3,4,5-tetrahydro-1-benzoxepine | HCID 22391789 | — |
| Product | 7-Chloro-9-methyl-5-methylsulfonylamino-2,3,4,5-tetrahydro-1-benzoxepine | HCID 22391796 | — |
Reaction Steps
0.6 g of 5-amino-7-chloro-9-methyl-2,3,4,5-tetrahydro-1-benzoxepine (Example 10b) were reacted with methanesulfonyl chloride analogously to Example 10c. 0.6 g of 7-chloro-9-methyl-5-methylsulfonylamino-2,3,4,5-tetrahydro-1-benzoxepine was obtained, m.p. 154-156° C. By subsequent alkylation with butyl iodide analogously to Example 11, 0.6 g of 5-(N-butyl-N-methylsulfonylamino)-7-chloro-9-methyl-2,3,4,5-tetrahydro-1-benzoxepine was obtained, m.p. 106-110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06333349B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-18991dc1f4b04e1d84db5973225e3782 |
| Source note | uspto-grants-2001_12 |