Sodium hydride → HCID 57754614, compound

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 3 of Example 1, from 55 mg (0.20 mmol) of 3-(3,4-dimethyl-benzoyl)-1H-quinolin-4-one, 10 mg of 60% sodium hydride, 55 mg (0.24 mmol) 2-bromomethyl-5-trifluoromethyl-furan and 0.7 mL of N,N-dimethylformamide. Yield: 70 mg of a white solid: LC-MSD, m/z for C24H18F3NO3 [M+H]+=426.4; HPLC retention time: 2.7 min.

Provenance & Evidence