Hydrochloric Acid → HCID 178433641, compound

Participants

Reaction Steps

To the product of Example 42 (0.042 g, 0.08 mmol) was added a saturated solution of hydrogen chloride in methanol, and the resulting solution was allowed to age for 18 h. The solvent was then evaporated, and the residue was azeotroped with toluene. The residue was crystallised from methanol-ethyl acetate, and recrystallised from hot ethanol to afford the title compound as a yellow solid; 1H NMR (500 MHz, DMSO-d6) 67 12.47 (br s), 9.05 (br s), 8.52 (1H, s), 8.14 (2H, d, J 9.0 Hz), 7.43 (4H, m), 7.10 (2H, d, J8.8 Hz), 3.46 (4H, m), 3.26 (4H, m), 2.28 (3H, s); MS (ES+) m/z 420/422[MH]+.

Provenance & Evidence