Sodium hydride → 3-(3,4-Dimethyl-benzoyl)-1-(6-methoxy-pyridin-2-ylmethyl)-1H-quinolin-4-one

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 3 of Example 1, from 50 mg (0.18 mmol) of 3-(3,4-dimethyl-benzoyl)-1H-quinolin-4-one, 9 mg (0.21 mmol) of 60% sodium hydride, 44 mg (0.22 mmol) 2-bromomethyl-6-methoxy-pyridine and 0.8 mL of N,N-dimethylformamide. Yield: 45 mg of a white solid: LC-MSD, m/z for C25H22N2O3 [M+H]+=399.3; HPLC retention time: 2.8 min.

Provenance & Evidence