p-Tolylacetic acid → N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester

HRID 2271131Notes

Reaction equation

HRID 2271131 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.Cl.[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[CH:19]([CH3:21])[NH:20][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 248474p-Tolylacetic acidHCID 862001092-Methylpropyl 2-aminopropanoate hydrochloride

Product 1

HCID 22492098N-[(4methylphenyl)acetyl]-D,L-alanine Iso-butyl Ester

Procedure

Following General Procedure B and using 4-methylphenylacetic acid (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example B above), the title compound was prepared as a solid having a melting point of 102°-104° C. The reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Workup

  1. customThe reaction was monitored by tlc on silica gel (Rf=0.6 in 33% ethyl acetate/hexanes) and purification
  2. extractionwas by extraction with Et2O

Sources & evidence

ORD record
ord-28da7d00e60e4ff9b608a69072ec8580
Source dataset
uspto-grants-2001_12
Patent number
US06333351B1

Reaction notes

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