(3-Methoxyphenyl)acetic acid → 2-[(3-Methoxyphenyl)acetamido]butyric acid isobutyl ester

HRID 2271139Notes

Reaction equation

HRID 2271139 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:7][CH:8]=1.[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 15719(3-Methoxyphenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 538243972-[(3-Methoxyphenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 3-methoxyphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared frollowing General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-1900cabf6dba4628bbcc18d71e0ac380
Source dataset
uspto-grants-2001_12
Patent number
US06333351B1

Reaction notes

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