3-Fluorophenylacetic acid → 2-[(3-Fluorophenyl)acetamido]butyric acid isobutyl ester

HRID 2271148Notes

Reaction equation

HRID 2271148 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 676173-Fluorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 540199252-[(3-Fluorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 3-fluorophenylacetic acid (Aldrich) and isobutyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-5e0bf5ffbf484b4d950a8acc5f16560d
Source dataset
uspto-grants-2001_12
Patent number
US06333351B1

Reaction notes

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