Sodium hydride → 1-[1-(6-Bromo-pyridin-2-yl)-ethyl]-3-(5,6-dimethyl-pyridine-2-carbonyl)-1H-quinolin-4-one

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Reaction Steps

Experimental conditions analogous to those described for Step 3 of Example 1, from 50 mg (0.18 mmol) of 3-(5,6-dimethyl-pyridine-2-carbonyl)-1H-quinolin-4-one, 9 mg (0.22 mmol) of 60% sodium hydride, 57 mg (0.22 mmol) of 2-bromo-6-(1-bromo-ethyl)-pyridine and 0.7 mL of N,N-dimethylformamide. Yield: 4.4 mg of a white solid: LC-MSD, m/z for C24H20BrN3O2 [M+H]+=462.0, 464.0; HPLC retention time: 2.0 min.

Provenance & Evidence