Phenylmethyl 4-{[N-(2,6-dimethylphenyl)carbamoyl]methyl}-3-oxopiperazinecarboxylate → N-(2,6-dimethylphenyl)-2-(2-oxopiperazinyl)-acetamide

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Reaction Steps

To a solution of compound 31 in methanol (10 mL) 10% palladium on carbon was added. The reaction vessel was charged with hydrogen (40 p.s.i) and agitated for 4 h. The catalyst was removed by filtration and the filtrate was concentrated and purified using column chromatography (1:15 MeOH:DCM) to yield compound 32 as a semi solid.

Provenance & Evidence