HCID 15433187, compound → tert-Butyl 4-[(10S)-3-{2-[1-(tert-Butoxycarbonyl)-4-piperidyl]ethyl}-13-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)-10-(ethoxycarbonyl)-4,7,12,12-tetraoxo-12lambda6-thia-5,8,11-triazatridec-1-yl]tetrahydro-1(2H)-pyridinecarboxylate
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH:16]([C:32](=[O:56])[NH:33][CH2:34][C:35](=[O:55])[NH:36][CH2:37][C@@H:38]([C:50]([O:52][CH2:53][CH3:54])=[O:51])[NH:39]C(=O)OCC2C=CC=CC=2)[CH2:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:21][CH2:20]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.NC[C@H](N[S:67]([CH2:70][C:71]12[C:77]([CH3:79])([CH3:78])[CH:74]([CH2:75][CH2:76]1)[CH2:73][C:72]2=[O:80])(=[O:69])=[O:68])C(OCC)=O.C(OC(N1CCC(CCC(CCC2CCN(C(OC(C)(C)C)=O)CC2)C(NCC(O)=O)=O)CC1)=O)(C)(C)C>>[C:28]([O:27][C:25]([N:22]1[CH2:21][CH2:20][CH:19]([CH2:18][CH2:17][CH:16]([C:32](=[O:56])[NH:33][CH2:34][C:35](=[O:55])[NH:36][CH2:37][C@@H:38]([C:50]([O:52][CH2:53][CH3:54])=[O:51])[NH:39][S:67](=[O:68])(=[O:69])[CH2:70][C:71]23[C:77]([CH3:79])([CH3:78])[CH:74]([CH2:75][CH2:76]2)[CH2:73][C:72]3=[O:80])[CH2:15][CH2:14][CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[CH2:9][CH2:10]2)[CH2:24][CH2:23]1)=[O:26])([CH3:31])([CH3:30])[CH3:29]Participants
4
Reactant 3
Product 1
Procedure
According to the procedure described for compound 29, starting with ethyl (2S)-3-amino-2-({[(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methyl]sulphonyl}amino)propanoate hydrochloride and compound 4.
Sources & evidence
- ORD record
- ord-7e9b7444c1e54591bc8f7680188dc2f8
- Source dataset
- uspto-grants-2001_12
- Patent number
- US06333338B1
Reaction notes
Loading…