Water → HCID 18330077, compound

Participants

Reaction Steps

Ethyl 3-[(2-amino-2-phenylethanoyl)amino]-2-[(2-naphthylsulphonyl)amino]propanoate hydrochloride (1.7 g, 3 mmol) and diisopropylethylamine (0.8 g, 6.2 mmol) are added, at room temperature, to a solution of 4-[1-(tert-butoxycarbonyl)-4-piperidyl]-2-{2-[1-(tert-butoxycarbonyl)-4-piperidyl]ethyl}butanoyl fluoride (ref. synthesis B-1) (1.55 g, 3 mmol) in 50 ml of dichloromethane. After stirring for 3 hours, water is added. The organic phase is washed with water, dried over sodium sulphate and evaporated to give the crude product, which is purified by flash chromatography (20/1 dichloromethane/methanol) to give 1.2 g of a white solid.

Provenance & Evidence