HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 6-methylnaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 6-Bromo-2-naphthalenol | HCID 27144 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 6-methylnaphthalen-2-ol | HCID 242834 | — |
Reaction Steps
React 6-bromo-2-naphthol with t-butyl dimethylsilyl chloride and imidazole, followed by adding n-BuLi and CH3I. Deprotect the hydroxyl group by reacting with n-Bu4F to produce the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06333435B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-e48013da5b4941b6aae10650e48bef19 |
| Source note | uspto-grants-2001_12 |