Thionyl Chloride → 2-Methyl-3,4,6-trifluorobenzoyl chloride

HRID 2271269Notes

Reaction equation

HRID 2271269 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[C:14]([F:15])=[C:13]([F:16])[CH:12]=[C:11]([F:17])[C:7]=1[C:8](O)=[O:9]>>[CH3:5][C:6]1[C:14]([F:15])=[C:13]([F:16])[CH:12]=[C:11]([F:17])[C:7]=1[C:8]([Cl:3])=[O:9]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 101303052-Methyl-3,4,6-trifluorobenzoic acid

Product 1

HCID 150076072-Methyl-3,4,6-trifluorobenzoyl chloride

Procedure

7 ml of thionyl chloride was added to 3.2 g of 2-methyl-3,4,6-trifluorobenzoic acid, followed by heating and refluxing for 1 hour. The reaction mixture was concentrated, giving 3.3 g of 2-methyl-3,4,6-trifluorobenzoyl chloride. Then 5 ml of toluene was added to the resulting 2-methyl-3,4,6-trifluorobenzoyl chloride to give a toluene solution.

Workup

  1. temperatureby heating
  2. temperaturerefluxing for 1 hour
  3. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-45dbf81ae9bb40cb888f935b180fec40
Source dataset
uspto-grants-2001_12
Patent number
US06333431B1

Reaction notes

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