Cyclopropylamine → HCID 178418304, compound

Participants

Reaction Steps

3.5 g of ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate was dissolved in 25 ml of ethanol, and thereto 0.84 ml of cyclopropylamine was added dropwise under ice-cooling. After stirring at room temperature for 30 minutes, the reaction mixture was concentrated. The residue was purified by silica gel column chromatography (eluent; dichloromethane : n-hexane=1:1) to give 2.7 g of ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-cyclopropylaminoacrylate.

Provenance & Evidence