HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 4-Quinolinol, 3-iodo-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-Hydroxyquinoline | HCID 69141 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Quinolinol, 3-iodo- | HCID 12376844 | — |
Reaction Steps
1H-Quinolin-4-one (2.90 g, 20 mmol, 1 equiv) in 5 mL of DMF was treated with 1.12 g of KOH (2 equiv) and 5.30 g of iodine (1.05 equiv) for 2 hours. The reaction was quenched by slow addition of saturated aqueous solution of Na2S2O3. Filtration gave 3-iodo-1H-quinolin-4-one as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-a663a3f815d4412d9d03fca6c3220b1e |
| Source note | uspto-grants-2009_07 |