Methylphenidate Hydrochloride → Methylphenidate

HRID 2271317Notes

Reaction equation

HRID 2271317 reaction equation
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl>O>[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

Participants

3

Reactant 1

HCID 9280Methylphenidate Hydrochloride

Product 1

HCID 4158Methylphenidate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a preferred manufacturing process, methylphenidate HCl and microcrystalline cellulose (Avicel PH-101) are blended in a Hobart Mixer. Purified water is added to the dry mixture and the wet granulation is extruded (MG-55 Multi granulator). The extrudate is then spheronized into pellets (Caleva Model#SPH250). The wet pellets are dried (Fluid Air Model#0050) and sieved (30 mesh<Acceptable<20 mesh).

Workup

  1. customThe wet pellets are dried (Fluid Air Model#0050)
  2. filtrationsieved (30 mesh<Acceptable<20 mesh)

Sources & evidence

ORD record
ord-93119d74154f46c3a6e359a34f56ebb6
Source dataset
uspto-grants-2015_09
Patent number
US09119809B2

Reaction notes

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