HCID 16659853, compound → HCID 178517320, compound

HRID 2271320Notes

Reaction equation

HRID 2271320 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][C@H:19]2[CH2:22][C@H:21]([C:23]([OH:25])=[O:24])[CH2:20]2)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[NH:8][C:7]12[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.FC1C=CC(OCC2CC(C(O)=O)C2)=C2C=1NC(=O)NC12CCCCC1.C(C1C=CC(O[C@H]2C[C@H](C(O)=O)C2)=C2C=1NC(=O)NC12CCCCC1)#N.FC1C=CC(OCC2(C(O)=O)CCC2)=C2C=1NC(=O)NC12CCCCC1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][C@@H:19]2[CH2:20][C@H:21]([C:23]([OH:25])=[O:24])[CH2:22]2)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[NH:8][C:7]12[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 4

HCID 16659853HCID 16659853, compoundHCID 16659855HCID 16659855, compoundHCID 178510096HCID 178510096, compoundHCID 178517321HCID 178517321, compound

Product 1

HCID 178517320HCID 178517320, compound

Procedure

trans-3-[(8′-Chloro-2′-oxo-2′,3′-dihydro-1′H-spiro[cyclohexane-1,4′-quina-zolin]-5′-yl)oxy]cyclobutanecarboxylic acid; 3-[(8′-fluoro-2′-oxo-2′,3′-dihydro-1′H-spiro[cyclohexane-1,4′-quinazolin]-5′-yl)oxymethyl]cyclobutanecarboxylic acid; trans-3-[(8′-cyano-2′-oxo-2′,3′-dihydro-1′H-spiro[cyclohexane-1,4′-quinaz-olin]-5′-yl)oxy]cyclobutanecarboxylic acid; 1-[(8′-fluoro-2′-oxo-2′,3′-dihydro-1′H-spiro[cyclohexane-1,4′-quinazolin]-5′-yl)oxymethyl]cyclobutanecarboxylic acid; trans-3-[(8′-chloro-2′-oxo-2′,3′-dihydro-1′H-spiro[cycloheptyl-1,4′-quina-zolin]-5′-yl)oxy]cyclobutanecarboxylic acid; and trans-3-[(8′-chloro-2′-oxo-2′,3′-dihydro-1′H-spiro[cyclopentyl-1,4′-quinazolin]-5′-yl)oxy]cyclobutanecarboxylic acid; or a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof.

Sources & evidence

ORD record
ord-9c6c81e2ea094a85a0a8b720716f5f0c
Source dataset
uspto-grants-2015_09
Patent number
US09119822B2

Reaction notes

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