DL-valine → HCID 118333561, compound

HRID 2271323Notes

Reaction equation

HRID 2271323 reaction equation
[NH2:1][CH:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4].[C:9]([NH:17][C@H:18]([C:20]([OH:22])=[O:21])[CH3:19])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>O>[C:9]([NH:17][C@H:18]([C:20]([OH:22])=[O:21])[CH3:19])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 1182DL-valineHCID 709778N-benzoyl-L-alanine

Product 1

HCID 118333561HCID 118333561, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
95 °C

Procedure

Twenty four grams of DL-valine and 19.3 g of N-benzoyl-L-alanine were suspended in 200 mL of deionized water. The suspension was heated to 95° C. to form a clear solution, which was cooled slowly. When the solution was cooled to room temperature after 2 hours, the precipitated crystals were separated by filtration, washed with 50 mL of deionized water, and dried to obtain 26.8 g of crystalline L-valine N-benzoyl-L-alanine complex (L-valine to N-benzoyl-L-alanine molar ratio of 1:1).

Workup

  1. customto form a clear solution, which
  2. temperaturewas cooled slowly
  3. temperatureWhen the solution was cooled to room temperature after 2 hours
  4. customthe precipitated crystals were separated by filtration
  5. washwashed with 50 mL of deionized water
  6. customdried

Sources & evidence

ORD record
ord-86231e5925954f78a659095389894bad
Source dataset
uspto-grants-2015_09
Patent number
US09120722B1

Reaction notes

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