HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bromomethyl)-6-(trifluoromethyl)pyridine → 3-(4-Methoxy-3-methyl-benzoyl)-1-(6-trifluoromethyl-pyridin-2-ylmethyl)-1H-[1,8]naphthyridin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bromomethyl)-6-(trifluoromethyl)pyridine | HCID 46941463 | — |
| Reactant | 3-(4-Methoxy-3-methyl-benzoyl)-1H-[1,8]naphthyridin-4-one | HCID 57754528 | — |
| Product | 3-(4-Methoxy-3-methyl-benzoyl)-1-(6-trifluoromethyl-pyridin-2-ylmethyl)-1H-[1,8]naphthyridin-4-one | HCID 57754685 | 18.2% |
Reaction Steps
Experimental conditions analogous to those described for Step 3 of Example 1, from 50 mg (0.17 mmol) of 3-(4-Methoxy-3-methyl-benzoyl)-1H-[1,8]naphthyridin-4-one, and 2-Bromomethyl-6-trifluoromethyl-pyridine 53 mg (0.22 mmol), to give 14 mg of desired compound. LCMS (M+H)+: 454.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-5b58e32923f54c7f880c1d3a4c376058 |
| Source note | uspto-grants-2009_07 |