HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(5-Dimethylcarbamoyl-pentyl)-n-(2-hydroxy-1-methyl-ethyl)-benzamide → 3-(5-Dimethylcarbamoyl-pent-1-ynyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(5-Dimethylcarbamoyl-pentyl)-n-(2-hydroxy-1-methyl-ethyl)-benzamide | HCID 59260243 | — |
| Reactant | 3-(5-Dimethylcarbamoyl-pent-1-enyl)-n-(2-hydroxy-1-methyl-ethyl)benzamide | HCID 67135391 | — |
| Product | 3-(5-Dimethylcarbamoyl-pent-1-ynyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide | HCID 11301529 | — |
Reaction Steps
The alkyne 8 (0.100 g, 0.3 mmol) was synthesized by Lindlar catalyzed reduction using method E to obtain a mixture of 16 and 3-(5-dimethylcarbamoyl-pentyl)-N-(2-hydroxy-1-methyl-ethyl)-benzamide (13) which were separated by reverse-phase HPLC chromatography (20% acetonitrile/80% water 20 min isocratic program) (16, 34 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120723B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-a2776b1a25004a5f8e00241d048e3c0e |
| Source note | uspto-grants-2015_09 |