HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromobenzyl bromide → 1-(3-Bromo-benzyl)-3-(4-methoxy-3-methyl-benzoyl)-1H-[1,8]naphthyridin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromobenzyl bromide | HCID 69979 | — |
| Reactant | 3-(4-Methoxy-3-methyl-benzoyl)-1H-[1,8]naphthyridin-4-one | HCID 57754528 | — |
| Product | 1-(3-Bromo-benzyl)-3-(4-methoxy-3-methyl-benzoyl)-1H-[1,8]naphthyridin-4-one | HCID 57754747 | 21.6% |
Reaction Steps
Experimental conditions analogous to those described for Step 3 of Example 1, from 50 mg (0.17 mmol) of 3-(4-Methoxy-3-methyl-benzoyl)-1H-[1,8]naphthyridin-4-one, and 1-Bromo-3-bromomethyl-benzene 55 mg (0.22 mmol), to give 17 mg of desired compound. LCMS (M+H)+: 463.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-f9bea21dcbde46fa8e04b2402b0899db |
| Source note | uspto-grants-2009_07 |