HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bromomethyl)-6-(trifluoromethyl)pyridine → 3-(2,3-Dihydro-benzo[1,4]dioxine-6-carbonyl)-1-(6-trifluoromethyl-pyridin-2-ylmethyl)-1H-quinolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bromomethyl)-6-(trifluoromethyl)pyridine | HCID 46941463 | — |
| Reactant | 3-(2,3-Dihydro-benzo[1,4]dioxine-6-carbonyl)-1H-quinolin-4-one | HCID 57754543 | — |
| Product | 3-(2,3-Dihydro-benzo[1,4]dioxine-6-carbonyl)-1-(6-trifluoromethyl-pyridin-2-ylmethyl)-1H-quinolin-4-one | HCID 57754574 | 18.8% |
Reaction Steps
Experimental conditions analogous to those described for Step 3 of Example 1, from 3-(2,3-Dihydro-benzo[1,4]dioxine-6-carbonyl)-1H-quinolin-4-one 70 mg (0.228 mmol) and 71.1 mg (0.296 mmol) of 2-Bromomethyl-6-trifluoromethyl-pyridine, to give 20 mg of desired compound. LCMS (M+H)+: 467.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-a307abfcf65e4143ba5a98e08a92a1d5 |
| Source note | uspto-grants-2009_07 |