HCID 59637316, compound → HCID 59637311, compound

HRID 2271419Notes

Reaction equation

HRID 2271419 reaction equation
[C:1]1([CH:7]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[C:15]([F:22])[CH:14]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CCO>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:14][C:15]=1[F:22]

Participants

3

Reactant 1

HCID 59637316HCID 59637316, compound

Product 1

HCID 59637311HCID 59637311, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The ethyl 2-phenyl-2-(3-fluoro-4-nitrophenyl)acetate was dissolved in a 1:1 mix of EtOH and EE (465 ml) and hydrogenated in an H-cube (1 bar, 25° C., 1 ml/min and 0.25 mol/L). After removal of the solvent and drying, 5.2 g (97.5%) of product could be obtained.

Workup

  1. customAfter removal of the solvent
  2. customdrying

Sources & evidence

ORD record
ord-4a3d82e5799b432aacd40d29a7e53056
Source dataset
uspto-grants-2015_09
Patent number
US09120756B2

Reaction notes

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