Benzoic Acid → HCID 178507854, compound

Participants

Reaction Conditions

Reaction Steps

A 250 mL round bottom flask was charged with solid minoxidil (21.209 g), 85 mL isopropanol, and 85 mL water. The system was heated from room temperature to approximately 75° C. with stirring, until the solids dissolved. A 50 mL round bottom flask was charged with benzoic acid (12.421 g), 21 mL of isopropanol, and 21 mL of water. The system was heated from room temperature to approximately 75° C. with stirring, until the solids dissolved. The benzoic acid solution was added to the minoxidil solution and the resulting system was cooled to approximately 69° C. and held at this temperature for one hour. Precipitation of white solids was observed. The system was slowly cooled to room temperature before being placed in a refrigerator with stirring for about one day. Solids were collected by vacuum filtration and dried under vacuum at room temperature, yielding 31.8 g of minoxidil:benzoic acid 1:1 monohydrate cocrystal (90% yield).

Provenance & Evidence